NDLI: Lipid and Carbohydrate Metabolites Changes in Exhaled Breath Condensate and Blood in Acute Exacerbation of Chronic Bronchitis and Chronic Obstructive Pulmonary Disease

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Lipid and Carbohydrate Metabolites Changes in Exhaled Breath Condensate and Blood in Acute Exacerbation of Chronic Bronchitis and Chronic Obstructive Pulmonary Disease

Content Provider	Semantic Scholar
Author	Makarevich, Aleksander E.
Copyright Year	2018
Abstract	Exhaled breath condensate (EBC) reflects the polyfunctionality of the lungs, the intensity and shifts of metabolic reactions. The aim was to investigate the changes of some lipid and carbohydrate intermediate metabolites as well enzymes as both in EBC and blood in acute exacerbation of chronic bronchitis (AECB) and chronic obstructive pulmonary disease (AECOPD). Methods: EBC was collected from in-patients with CB (n=12) and mild-moderate-severe COPD (COPD1-2,3 — respectively) (n=49). We detected both in EBC and blood: total lipids (TL), phospholipids (TPhL) and cholesterol (TCL); free cholesterol (FCL) and etheric cholesterol (ECL), triglycerides (TG), free fatty acids (FFA), NH3, lactic acid (LA); activity of pyruvate kinase (PK) and adenylate kinase (AK), pyruvic (PvA), succinic (ScA) and oxaloacetic acids (OaA) as well as EBC surfaceactive properties (SAP). Results. Exhaled TL (eTL) were increased in CB, COPD1,2 vs. the control and then were decreased in COPD3 up to the control value. eTG were increased in COPD2,3 by 18% vs. the control while eFFA were reduced in COPD1,2,3 by 19% vs. the control. eTPhL were significantly enhanced in all groups without difference between them. SAP was significantly decreased in CB, COPD1,2 but more in COPD3 (by 50% vs. the control). NH3 level was significantly elevated both in EBC and blood vs. the control, but without difference between the groups. ScA in COPD1,2 both in EBC and blood exceeded the control more than 5 times while AK activity in EBC and blood was significantly reduced (by 1,3 times) in mixed COPD1,2 group. Conclusions: The changes of these metabolites and enzymes occurred more in EBC and less in blood plus did not correlate with COPD severity (excluding SAP).
Starting Page	30
Ending Page	36
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://plr.com.ua/index.php/journal/article/download/40/38
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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