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Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l -prolyl- l -leucyl glycinamide (PLG) tripeptide
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oliver, Martin Gadais, Charlène García-Pindado, Júlia Teixidó, Meritxell Lensen, N. Chaume, G. Brigaud, Thierry |
| Copyright Year | 2018 |
| Abstract | The synthesis of four CF3-proline analogues of the PLG peptide is reported. Our results show that the incorporation of trifluoromethylated amino acids (Tfm-AAs) at the N-terminal position of a peptide significantly increases its hydrophobicity. In addition, depending on the relative configuration and the position of the CF3 group, Tfm-AAs can also promote passive diffusion transport. |
| Starting Page | 14597 |
| Ending Page | 14602 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C8RA02511H |
| Volume Number | 8 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/ra/c8ra02511h/c8ra02511h1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C8RA02511H |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |