NDLI: Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings

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Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings

Content Provider	Semantic Scholar
Author	Chiu, S. Paulose, Cheramadathikudyil Skaria Mishra, Ram Kinker
Copyright Year	1981
Abstract	The mechanism of action subserving the potential anti-Parkinsonian properties of L-prolyl-L-leucyl-glycinamide (PLG) was investigated in behavioural and neurochemical models of dopaminergic function in the rat. Acute administration of PLG (20 and 40 mg kg-1 SC) failed to alter appreciably the intensity of the cataleptic response elicited by haloperidol (3 mg kg-1 IP). By contrast, chronic PLG treatment (20, 40 and 80 mg kg-1 SC twice daily for five days) significantly attenuated haloperidol-induced catalepsy. The effect of PLG on in vitro dopamine/neuroleptic receptor binding in rat striatum as differentially labelled by apomorphine and spiroperidol was also examined. PLG selectively enhanced the affinity of the specific binding of agonist [3H] apomorphine to dopamine receptors in the striatum, but had no effect on [3H] spiroperidol binding. The behavioural and biochemical results obtained in the present study raise the possibility that PLG may facilitate nigro-striatal dopaminergic neurotransmission through interacting with a unique PLG receptor functionally coupled to the dopamine receptor-adenylate cyclase complex.
Starting Page	105
Ending Page	111
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/S0196-9781(81)80019-8
PubMed reference number	6113579
Journal	Medline
Volume Number	2
Alternate Webpage(s)	https://dyuthi.cusat.ac.in/xmlui/bitstream/handle/purl/578/Simon%20Chiu%20and%20others(1980)july7.PDF?sequence=1
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0196978181800198
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0196978181800198?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0196-9781%2881%2980019-8
Journal	Peptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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