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Presence of early ischemic changes on computed tomography depends on severity and the duration of hypoperfusion: a single photon emission-computed tomographic study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hirano, Teruyuki Yonehara, Toshiro Inatomi, Yuichiro Hashimoto, Yoichiro Uchino, Makoto |
| Copyright Year | 2005 |
| Abstract | BACKGROUND AND PURPOSE To evaluate the clinical significance of early ischemic change (EIC) on computed tomography (CT), pertinent factors that contribute to the appearance of EIC. METHODS Both CT and technetium-99m hexamethylpropylene amine oxime were performed on a total of 53 patients (34 men, 19 women, mean 69.7 years old) with acute embolic stroke within 6 hours of onset. Patients were excluded if they showed definite clinical recovery or were administered thrombolytic agents. EIC was evaluated using Alberta Stroke Program Early CT Score (ASPECTS). Residual cerebral blood flow (CBF) was determined on SPECT. Variables that were considered pertinent were patients' age, gender, neurological severity, symptom duration, and residual CBF. Using significant pertinent factors for EIC, separate analyses of brain swelling without hypoattenuation and parenchymal hypoattenuation were performed. RESULTS Patients with EIC (n=37) showed severe neurological deficits, a longer duration and severe hypoperfusion. A positive correlation was observed between ASPECTS and residual CBF (P=0.002; Kruskal-Wallis test). A logistic-regression analysis revealed that both symptom duration (r=0.024, P=0.006) and severity of hypoperfusion (r= -12.167, P=0.006) are independent factors related to EIC. Symptom duration and residual CBF were significantly different among patients with parenchymal hypoattenuation (n=32), brain swelling without hypoattenuation (n=5), and no EIC (P=0.018 and P=0.001, respectively; one-way ANOVA). CONCLUSIONS The presence of EIC is determined by the duration and the degree of hypoperfusion. This finding supports the hypothesis that tissue damage may be evaluated by a combination of onset time and the presence of EIC. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/36/12/2601.full.pdf?download=true |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/early/2005/10/27/01.STR.0000189990.31225.82.full.pdf?download=true |
| Alternate Webpage(s) | http://stroke.ahajournals.org/content/strokeaha/early/2005/10/27/01.STR.0000189990.31225.82.full.pdf |
| PubMed reference number | 16254222v1 |
| Volume Number | 36 |
| Issue Number | 12 |
| Journal | Stroke |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amine Oxidase (Copper-Containing) Amines Brain Edema Cerebrovascular Circulation Cerebrovascular accident Exclusion Fibrinolytic Agents Oximes Patients Photons Serous Endometrial Intraepithelial Carcinoma Soft Tissue Injuries Technetium 99m Technetium Tc 99m Exametazime Tomography, Spiral Computed X-Ray Computed Tomography adult pineal parenchymal tumor hypoperfusion nervous system disorder |
| Content Type | Text |
| Resource Type | Article |
