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Stimulation of nerve growth factor synthesis/secretion by 1,4-benzoquinone and its derivatives in cultured mouse astroglial cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Takeuchi, R. Murase, Kiyoshi Furukawa, Yusuke Furukawa, Shigetada Hayashi, Kyozo |
| Copyright Year | 1990 |
| Abstract | Previously we reported that astroglial cells cultured from mouse brain synthesize and secrete nerve growth factor (NGF) and that, in quiescent cells, catecholamines markedly increase the NGF content in the conditioned medium (CM). We wished to further assess the structural properties required for exhibition of such effect of compounds containing a ring structure analogous to that of catechol on astroglial NGF synthesis. During our study, we found that hydroquinone, which was confirmed not to stimulate NGF synthesis in mouse fibroblast cells in another of our investigations, is a potent stimulator of NGF synthesis in astroglial cells and that 1,4-benzoquinone, an oxidized form of hydroquinone, is a more effective stimulator than hydroquinone itself. In addition, the results of experiments with 1,2-benzoquinone derivatives indicated that the presence of a long aliphatic side chain in the molecule eliminates the stimulatory effect of 1,4-benzoquinone on NGF synthesis in astroglial cells. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82418514.pdf |
| PubMed reference number | 2307236v1 |
| Volume Number | 261 |
| Issue Number | 1 |
| Journal | FEBS letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 1,4-benzoquinone 2-benzoquinone Catecholamines Cell secretion Culture Media, Conditioned Growth Factor NGF protein, human catechol hydroquinone |
| Content Type | Text |
| Resource Type | Article |
