Recombinant human basic fibroblast growth factor (rhbFGF) induces secretion of nerve growth factor (NGF) in cultured rat astroglial cells

Content Provider	Semantic Scholar
Author	Fukumoto, Hiroaki Kakihana, Mitsuru Suno, Masahiro
Copyright Year	1991
Abstract	Recombinant human basic fibroblast growth factor (rhbFGF) was found to induce secretion of nerve growth factor (NGF) in cultured astrocytes from rat brain. The induction was concentration dependent; a maximum increase of 2-fold was observed at concentrations of 3-10 ng/ml or rhbFGF. When rhbFGF was added to the astrocytes, the induction occurred within 8 h and leveled off after 12 h. Antiserum against rhbFGF completely blocked the induction. Maximum induction occurred under serum-free culture conditions and in cultures with a high cell density. These results suggest that rhbFGF may exert a neurotrophic effect on the central nervous system through the induction of NGF secretion by astrocytes.
Starting Page	221
Ending Page	224
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(91)90863-O
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409190863O
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409190863O?dgcid=api_sd_search-api-endpoint
PubMed reference number	2027522
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2891%2990863-O
Journal	Medline
Volume Number	122
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article