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Ageing and endothelial dysfunction
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vanhoutte, Paul Michel |
| Copyright Year | 2004 |
| Abstract | Little doubt remains that the endothelium contributes to local control of tone and propensity to grow of underlying vascular smooth muscle. In order to accomplish this, the endothelial cells generate both relaxing and growthinhibiting factors (nitric oxide [NO], prostacyclin, endothelium-derived hyperpolarizing factor [EDHF]), and vasoconstrictor and growth-promoting substances (superoxide anions, endoperoxides, thromboxane A2, endothelin [ET]-1, angiotensin II; Fig. 1)[1–18]. The contribution of each of those signals varies from blood vessel to blood vessel. A number of variables can upregulate or downregulate the ability of the endothelial cells to release ‘good’ (relaxing and growth-inhibiting) and ‘bad’ (contracting and growthpromoting) factors. Thus, appropriate intake of antioxidants, red wine, green tea and omega-3 unsaturated fatty acids improves endothelial function, as does regular exercise. Conversely, smoking, excessive cholesterol intake, hyperglycaemia and hypertension all cause considerable impairment of the ability of endothelial cells to release ‘good’ messengers (in particular NO) and augment their propensity to release ‘bad’ factors. Impaired release of NO is of major importance because this endothelial mediator not only relaxes vascular smooth muscle, but also inhibits several processes that ultimately facilitate development of atherosclerosis, rendering endothelial dysfunction the key initial step in the formation of the atherosclerotic plaque (Fig. 2)[8,11,12,19–25]. The present review discusses the negative impact of ageing on endothelial function, which sets the scene for development of vascular disease[26–35]. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.argi9solutions.com/images/Eur%20Heart%20J%20Suppl-2002-Vanhoutte-A8-A17.pdf |
| Alternate Webpage(s) | https://watermark.silverchair.com/A8.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAjkwggI1BgkqhkiG9w0BBwagggImMIICIgIBADCCAhsGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMWfqg3xLR_XYDZXwLAgEQgIIB7C5TOvYdQw7fbBDz0vn4qhBFIKUYyBhK_nbDM3TG8kinz9E0pFOLyJ_8Nov8vjYem9m72ev0kSk6rDcR6OJmGUcfUahcd-69fduFmGICBBe6pyVr3bZ_fGtSvf8_SiU_GBKD-dndV6sXBQRbDxe8HI-Y01oFt9ek4M3srHiha-w1AyJppx6sPf6ZJYgwuSdo9x5wxhiJM67XPscss-8nHUD1Mz8DCAVYKuHs-xJOmNQkmWKQLcnt30EemI-nmCHRdRaETNBLlHkpf8c2MslhdG-oye30FPNv27NuidzS0xWMnLlgAIpScGUAFvJmrlCUzK-D62W_EOeZBUKH96BSzCADKi_6HrQHlrsyJaOiI8bcVTidH6nOiuh5CSqeWX-IrKq6nliA2HlQwhnW49TJTv5x51uQC7CCAzUPCZ9SGxKA6enq3o5tzjkfnjGAalWkDbo8PabR7ejGEstU4u1tU6h70SRG7d-FXhSwDHTRXvHCLZrjvzadmGqQRXuQ-jsMNYHTmBDbAxV7uaIIpH1HEzUmDkqLuzMj3PZ7vhRmst7UHhk0WeKnCcY5MDCKCsTALALAABejYT_g0FHdFeh2IEVbEYLBqBwCOvb0nvHToHaTyVTX4eydUf87QBzKlLtUskC4GVMXqsDAlpH8FQ |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aging Angiotensin II Angiotensins Anions Antioxidants Atherosclerosis Blood Vessel Cholesterol Contract agreement Dental Plaque Endothelial Cells Endothelin A Receptor Antagonists Epoprostenol Fatty Acids Fatty Acids, Unsaturated Fatty Liver Hyperglycemia Hypertensive disease Inhibition Mediator brand of benfluorex hydrochloride Muscle, Smooth, Vascular Nitric Oxide Plant Extracts Promotion (action) Smoke Smooth muscle (tissue) Superoxides Thromboxane A2 Thromboxanes Vascular Neoplasms Xfig |
| Content Type | Text |
| Resource Type | Article |
