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L-arginine in the clinical arena: tool or remedy?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lüscher, Thomas Felix Haefeli, Walter E. |
| Copyright Year | 1993 |
| Abstract | B efore the recent discoveries on the functional importance of the endothelium in the regulation of vascular tone and growth as well as platelet function and coagulation, it was obvious that the intima was a major target of various cardiovascular injuries.1-5 Indeed, although endothelial cells are not denuded in diseased blood vessels (except at late stages), the morphology of the cells as well as the subintimal space does exhibit changes in hypertension, diabetes, hypercholesterolemia, atherosclerosis, reperfusion injury, and cyclosporin toxicity. A crucial discovery by Furchgott and Zawadzki in 19806 was the fact that endothelial cells regulate the tone of the underlying vascular smooth muscle. Later on, it became clear that the mediator of endotheliumdependent relaxations was nitric oxide formed from L-arginine7-10 via the activity of a constitutively expressed enzyme, nitric oxide synthase.11-13 Hence, nitric oxide represents the endogenous nitrovasodilator, which activates soluble guanylyl cyclase in vascular smooth muscle14 and in turn causes profound relaxation by decreasing intracellular Ca2` levels15 and dephosphorylating myosin light chains.'6 The importance of this pathway in the circulation was further supported by the discovery that nitric oxide not only causes relaxation but also exerts potent inhibitory effects on platelet function'517"18 and possibly on macrophages. |
| Starting Page | 046604 |
| Ending Page | 046604 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/87/5/1746.full.pdf?download=true |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/87/5/1746.full.pdf |
| PubMed reference number | 8491028v1 |
| Volume Number | 87 |
| Issue Number | 5 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Arginine Atherosclerosis Blood Platelets Blood Vessel Cyclosporine Diabetes Mellitus Endothelial Cells Guanylate Cyclase Hypercholesterolemia Hypertensive disease Mediator brand of benfluorex hydrochloride Muscle, Smooth, Vascular Nitric Oxide Reperfusion Injury Smooth muscle (tissue) Soluble Guanylate Cyclase, human |
| Content Type | Text |
| Resource Type | Article |
