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Enantioselective γ-Alkylation of α,β-Unsaturated Malonates and Ketoesters by a Sequential Ir-Catalyzed Asymmetric Allylic Alkylation/Cope Rearrangement.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, W. Timothy Okamoto, Noriko Alexy, Eric J. Allen Y. Tran, Kristy Stoltz, Brian M. |
| Copyright Year | 2016 |
| Abstract | A catalytic, enantioselective γ-alkylation of α,β-unsaturated malonates and ketoesters is reported. This strategy entails a highly regio- and enantioselective iridium-catalyzed α-alkylation of an extended enolate, and a subsequent translocation of chirality to the γ-position via a Cope rearrangement. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/jacs.6b02153 |
| PubMed reference number | 27052660 |
| Journal | Medline |
| Volume Number | 138 |
| Issue Number | 16 |
| Alternate Webpage(s) | http://authors.library.caltech.edu/66506/3/ja6b02153_si_001.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/jacs.6b02153 |
| Journal | Journal of the American Chemical Society |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |