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Enantioselective Michael addition of malonates to α,β-unsaturated ketones catalyzed by 1,2-diphenylethanediamine
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Weiqi Ye, Ling Ying Shi, Zhichuan Zhao, Zhigang Li, Xuefeng |
| Copyright Year | 2018 |
| Abstract | A general and highly enantioselective Michael addition of malonates to cinnamones and chalcones has been developed. The commercially available 1,2-diphenylethanediamine could be directly utilized as the organocatalyst to furnish the desired adducts in satisfactory yield (61–99%) and moderate to excellent enantiopurity (65 to >99% ee). β-Ketoester was also a competent donor and was employed to construct densely functionalized cyclohexenones via a tandem Michael-aldol condensation process. |
| Starting Page | 41699 |
| Ending Page | 41704 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C8RA07809B |
| Volume Number | 8 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/ra/c8ra07809b/c8ra07809b1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |