NDLI: Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation.

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Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation.

Content Provider	Semantic Scholar
Author	Teng, S. K. Chen, Yung-Yi Chou, Po-Chien Chiang, Yu-Chi Tseng, S. Wu, Kou-Juey
Copyright Year	2004
Abstract	The c-myc proto-oncogene encodes a ubiquitous transcription factor involved in the control of cell growth and differentiation and implicated in inducing tumorigenesis. Understanding the function of c-Myc and its role in cancer depends upon the identification of c-Myc target genes. Heat shock protein 90 (HSP90) is involved in the folding of proteins such as signal transduction molecules (Src, Raf1, cdk4) and steroid receptors and in enhancing the activity of telomerase and nitric-oxide synthase. Here we show that c-Myc directly activates HSP90A transcription. c-Myc-mediated induction of HSP90A transcription occurs in different tissues, is independent of cell proliferation, and is mediated by a c-Myc binding site in the proximal promoter region of HSP90A gene. Overexpression of HSP90A in Rat1a cells induces transformation. Short interference RNA of HSP90A/Hsp86alpha reduces transformation activity in HeLa and RatMyc cells. These results indicate that by induction of HSP90A c-Myc may control the activity of multiple signal pathways involved in cellular transformation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ntur.lib.ntu.edu.tw//bitstream/246246/2006111501221911/1/5427.pdf
PubMed reference number	14724288v1
Volume Number	279
Issue Number	15
Journal	The Journal of biological chemistry
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Carcinogenesis Cell Proliferation HSP90 Heat-Shock Proteins HSP90AA1 gene HSP90AA1 wt Allele HeLa Cells Heat-Shock Proteins 70 Ligand Binding Domain MYC wt Allele Nitric Oxide Synthase Oncogenes Promoter Regions, Genetic Proto-Oncogene Proteins c-myc Proto-Oncogenes RNA Receptors, Steroid Shock Signal Transduction Steroids TRANSCRIPTION FACTOR Telomerase cell growth metaplastic cell transformation
Content Type	Text
Resource Type	Article

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