NDLI: Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway.

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Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway.

Content Provider	Semantic Scholar
Author	Huang, Haili Hu, Min Zhao, Rui Li, Peng Li, Mingyi
Copyright Year	2013
Abstract	The aim of the present study was to evaluate the antitumor mechanism of dihydromyricetin (DHM). Results showed that DHM significantly inhibited cell viability of HepG2 and Hep3B cells in a dose-dependent manner. DHM induced G2/M cell-cycle arrest in HepG2 and Hep3B cells by altering the expression of cell cycle proteins such as cyclin A, cyclin B1, Cdk1, p53, Cdc25c, p-Cdc25c Chk1 and Chk, which are critical for G2/M transition. Knockdown of p53 and Chk1 in HepG2 cells did not affect G2/M phase arrest caused by DHM. Furthermore, G2/M arrest induced by DHM can be disrupted by Chk2 siRNA. These findings indicate that DHM inhibits the growth of hepatocellular carcinoma (HCC) cells via G2/M phase cell cycle arrest through Chk1/Chk2/Cdc25C pathway. The present study identified effects of DHM in G2/M phase arrest in HCC and described detailed mechanisms of G2/M phase arrest by this agent, which may contribute to its overall cancer preventive efficacy in HCC.
Starting Page	228
Ending Page	232
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/or/30/5/2467/download
PubMed reference number	24002546v1
Alternate Webpage(s)	https://doi.org/10.3892/or.2013.2705
DOI	10.3892/or.2013.2705
Journal	Oncology reports
Volume Number	30
Issue Number	5
Language	English
Access Restriction	Open
Subject Keyword	Cardiac Arrest Cell Cycle Arrest Cell Survival Cyclin A Cyclin B1 Liver carcinoma Negative Regulation of Mitosis Neoplasms dihydromyricetin
Content Type	Text
Resource Type	Article

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