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Synthesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic food mutagen
| Content Provider | Semantic Scholar |
|---|---|
| Author | Collins, Christopher J. Bupp, James E. Tanga, Mary J. |
| Copyright Year | 2003 |
| Abstract | The synthesis of the heterocyclic food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) 7, is reported. PhIP 7 was synthesized in six steps from commercially available 2,3-diaminopyridine 1 in 6% overall yield. This route features a new ring closure reagent, Ndichloromethylene-p-toluenesulfonamide, to assemble the imidazo[4,5-b]pyridine ring system and uses a Suzuki coupling to introduce an aryl ring onto the heterocyclic core as the last synthetic step. |
| File Format | PDF HTM / HTML |
| DOI | 10.3998/ark.5550190.0003.a12 |
| Volume Number | 2002 |
| Alternate Webpage(s) | http://www.arkat-usa.org/get-file/19284/ |
| Alternate Webpage(s) | https://doi.org/10.3998/ark.5550190.0003.a12 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
