NDLI: DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rats

Please wait, while we are loading the content...

DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rats

Content Provider	Scilit
Author	Takayama, Kyoko Yamashita, Katsumi Wakabayashi, Keiji Sugimura, Takashi Nagao, Minako
Copyright Year	1989
Description	Journal: Japanese Journal of Cancer Research 2‐Amino‐l‐methyl‐6‐pheny]imidazo[4,5‐b]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine by weight in cooked foods. This mutagen was found to produce DNA adducts in all ten tested organs of rats using the$ ^{32}$P‐postlabeling method. The level of DNA adducts in the pancreas, kidney and liver increased dose‐dependently and feeding tinie‐dependently up to four weeks. When diet containing 0.05% PhIP was given to rats for four weeks, levels of PhIP‐DNA adducts were relatively high in the lung, pancreas and heart, being around 20 per $10^{7}$ nucleotides, and lowest in the liver, being 2.20 per $10^{7}$ nucleotides. Thus, PhIP showed a unique feature in the formation of DNA adducts compared to other mutagenic and carcinogenic heterocyclic amines, which produce the highest level of DNA adducts in the liver.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917929/pdf https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.1989.tb01644.x
Ending Page	1148
Page Count	4
Starting Page	1145
ISSN	09105050
DOI	10.1111/j.1349-7006.1989.tb01644.x
Journal	Japanese Journal of Cancer Research
Issue Number	12
Volume Number	80
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1989-12-01
Access Restriction	Open
Subject Keyword	Journal: Japanese Journal of Cancer Research 2‐amino‐l‐methyl‐6‐phenylimidazo[4 5‐b]pyridine (phip) 32p‐postlabeling Method Heterocyclic Amine
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Detection of Guanine-C8-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Adduct as a Single Spot on Thin-layer Chromatography by Modification of $the^{32}$P-Postlabeling Method

Induction of Intestinal Adenocarcinomas by 2-Amino-l-methyl-6-phenylimidazo-[4,5-b] pyridine in Nagase Analbuminemic Rats

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) retards mammary gland involution in lactating Sprague–Dawley rats

Formation and inhibition of the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a model system

Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues

Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine

Synthesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic food mutagen

Chemoprevention by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced Mammary Gland Carcinogenesis in Rats

Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rats

Similar Documents

Detection of Guanine-C8-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Adduct as a Single Spot on Thin-layer Chromatography by Modification of $the^{32}$P-Postlabeling Method

Induction of Intestinal Adenocarcinomas by 2-Amino-l-methyl-6-phenylimidazo-[4,5-b] pyridine in Nagase Analbuminemic Rats

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) retards mammary gland involution in lactating Sprague–Dawley rats

Formation and inhibition of the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a model system

Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues

Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine

Synthesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic food mutagen

Chemoprevention by Nimesulide, a Selective Cyclooxygenase-2 Inhibitor, of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced Mammary Gland Carcinogenesis in Rats

Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Rats