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Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Yun-Jun Chao, Hui Tan, Li-Feng Yuan, Y. Ji, Liang-Nian |
| Copyright Year | 2005 |
| Abstract | A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)(2)(PYNI)](2+) (bpy=2,2'-bipyridine, PYNI=2-(2'-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and (1)H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)(2)(PYNI)](2+) binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jinorgbio.2004.10.030 |
| Alternate Webpage(s) | https://ww2.chemistry.gatech.edu/~lw26/bCourse_Information/nucleic_acid_biochem/articles/chao_j_inorg_chem_2004.pdf |
| PubMed reference number | 15621286 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jinorgbio.2004.10.030 |
| Journal | Medline |
| Volume Number | 99 |
| Issue Number | 2 |
| Journal | Journal of inorganic biochemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |