NDLI: eu Partnership for Advanced Computing in Europe 1 Massively Parallel Algorithm for Multiple Sequence Alignment Based on Artificial Bee Colony

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eu Partnership for Advanced Computing in Europe 1 Massively Parallel Algorithm for Multiple Sequence Alignment Based on Artificial Bee Colony

Content Provider	Semantic Scholar
Author	Borovska, Plamenka Gancheva, Veska
Copyright Year	2013
Abstract	In silico biological sequence processing is a key task in molecular biology. This scientific area requires powerful computing resources for exploring large sets of biological data. Parallel in silico simulations based on methods and algorithms for analysis of biological data using high-performance distributed computing is essential for accelerating the research and reducing the investment. Multiple sequence alignment is a widely used method for biological sequence processing. The goal of this method is DNA and protein sequences alignment. This paper presents an innovative parallel algorithm MSA_BG for multiple alignment of biological sequences that is highly scalable and locality aware. The MSA_BG algorithm we describe is iterative and is based on the concept of Artificial Bee Colony metaheuristics and the concept of algorithmic and architectural spaces correlation. The metaphor of the ABC metaheuristics has been constructed and the functionalities of the agents have been defined. The conceptual parallel model of computation has been designed and the algorithmic framework of the designed parallel algorithm constructed. Experimental simulations on the basis of parallel implementation of MSA_BG algorithm for multiple sequences alignment on heterogeneouc compact computer cluster and supercomputer BlueGene/P have been carried out for the case study of the influenza virus variability investigation. The performance estimation and profiling analyses have shown that the parallel system is well balanced both in respect to the workload and machine size.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.prace-project.eu/IMG/pdf/wp114.pdf
Alternate Webpage(s)	http://www.prace-ri.eu/IMG/pdf/wp114.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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