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L’effet des différents facteurs de croissance sur la viabilité et la prolifération des ostéoblastes scoliotiques
| Content Provider | Semantic Scholar |
|---|---|
| Author | Circo, Alin B. |
| Copyright Year | 2009 |
| Abstract | The Adolescent Idiopathic Scoliosis (AIS) is a debilitating condition and as a result often produces significant pain, impaired daily functioning and a deterioration of the quality of life. For patients who do not respond to conservative treatment, spinal fusion using bone grafts has become a treatment of choice to stabilize the spine. The more accurate knowledge of the factors involved in osteogenesis and the bone formation can shorten the healing process and reintegrate patients into their daily activities in a shorter period of time. Platelets can play an important role in the first stage of the healing of fractures and they are a source of several autologous growth factors that support the proliferation and differentiation of osteoblasts in vivo and in vitro. A wide variety of techniques and approaches have been investigated for performing spinal fusion, yet surgeons continue to investigate alternative methods with the goal of improving surgical outcome and minimizing morbidity. We can use these methods to: 1.Reduce the relatively long time needed for healing fractures 2. Patients with prosthesis could benefit of a shorter convalescent time 3. Several congenital diseases could be easier to correct and 4. We could stimulate the vertebral fusion 5. Develop new therapeutic techniques, including that of the processes regulating bone remodelling and regeneration of bone tissue. In the present study, we tried to find whether the insulin growth factor (IGF) and the vascular endothelial growth factor (VEGF) have an influence on the scoliotic osteoblasts in vitro cell cultures and we compared the results with those obtained in the same condition but by stimulating osteoblasts with melatonin. This preliminary study was performed on |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/2853/Circo_Alin_B_2009_Memoire.pdf;sequence=4 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
