NDLI: Cancer biomarkers: easier said than done.

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Cancer biomarkers: easier said than done.

Content Provider	Semantic Scholar
Author	Pritzker, Kenneth P. H.
Copyright Year	2002
Abstract	BACKGROUND Biological and technical advances have led to greatly increased research and development of cancer biomarkers. This overview lists some of the challenges and barriers to developing novel effective cancer biomarkers and enablers to facilitate cancer biomarker development. METHODS Current scientific literature regarding development of biomarkers for cancer and other diseases was reviewed. RESULTS Challenges to developing cancer biomarkers include better understanding of biological heterogeneity, including host/tumor heterogeneity; analytical factors, such as interferences and analytical sensitivity; clinical pathologic factors, such as current histopathologic standards; and health service and market factors. More standardized biomarker definitions, standardization of cancer biology terminology, and high-quality reference materials (specimen and clinical data repositories) were identified as factors required to support advances in cancer biomarkers. CONCLUSIONS With the above enablers, novel cancer biomarkers may be useful, both for assessing early and established neoplasia more precisely and for contributing data toward development of novel practical concepts regarding cancer biology.
File Format	PDF HTM / HTML
DOI	10.1093/clinchem/48.8.1147
PubMed reference number	12142366
Journal	Medline
Volume Number	48
Issue Number	8
Alternate Webpage(s)	http://clinchem.aaccjnls.org/content/clinchem/48/8/1147.full.pdf
Alternate Webpage(s)	https://doi.org/10.1093/clinchem%2F48.8.1147
Journal	Clinical chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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