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Long-term abstinent alcoholics have a blunted blood glucose response to 2-Deoxy-d-glucose.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Umhau, John C. Petrulis, Sarah G. Diaz, Rosalyn Riggs, Patti A. Biddison, James R. George, David Ted |
| Copyright Year | 2002 |
| Abstract | AIMS In this study we explored the relationship between alcohol and carbohydrate consumption in long-term abstinent alcoholics. METHODS We employed an established laboratory paradigm which allowed us to stimulate and measure dietary intake. 2-Deoxy-d-glucose (2-DG) is a glucose analogue that causes an intracellular energy deprivation resulting in exaggerated food consumption and a compensatory metabolic response to raise blood glucose. Using a double-blind design, we gave an infusion of 25 mg/kg 2-DG or placebo to 20 long-term abstinent alcoholics and 19 healthy volunteers. RESULTS There were no baseline differences in any dietary, behavioural or biochemical variables. As expected, 2-DG increased caloric consumption and blood glucose levels in a time-dependent fashion. There were no differences in food consumption between the alcoholics and the healthy volunteers following the 2-DG stimulus. However, the alcoholic group had a significantly blunted response in blood glucose. CONCLUSIONS The origin of this atypical blood glucose response may antedate the onset of alcoholism, or it may be secondary to alcohol-related damage that persists beyond 6 months. Previous accounts of increased sweet consumption in alcoholics were not substantiated, although they may be present in the peri-withdrawal period. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/alcalc/37.6.586 |
| PubMed reference number | 12414552 |
| Journal | Medline |
| Volume Number | 37 |
| Issue Number | 6 |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/alcalc/37/6/10.1093_alcalc_37.6.586/1/370586.pdf?Expires=1497487768&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=fbHBpE~WniI0KlOWNZ~aeHB2jQwHYKsLW88sM9N-l2xr4f0AqigddvqQYpsyXK3xfiKUGGcbVlcqO4TjZnfEfq6-wSysVmvOYqIzUnbuVlIXLAoUCSJix6mjZJW00ZrTfCLiMoROneNQg4XYO2b6ryBxcvzvfwWv6I6XjVGiu6RC8lHRpQc6ksgIj7IT3HDNxosjnWkru-ubA4YhWLYR2hPEG8W16fHqveF6suzc8vz4sQx0IIWoPj0gdnC2-d9UkkQYzzUjU7Pm0l2J0oj9JFnlK0NnHPeweSL2QV0ow~5zBdMOltv4qDiucOTqBfRdyxu~JlotJhvTkgnhd7mWug__ |
| Alternate Webpage(s) | https://doi.org/10.1093/alcalc%2F37.6.586 |
| Journal | Alcohol and alcoholism |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
