Unlike 2-deoxy-d-glucose, 3-O-methyl-d-glucose does not induce long-term potentiation in rat hippocampal slices

Content Provider	Semantic Scholar
Author	Xu, Yanyan Krnjević, Krešimir
Copyright Year	2001
Abstract	Equimolar replacement of 10 mM glucose by 2-deoxy-D-glucose (2-DG) causes substantial depression followed by a sharp and sustained potentiation of CA1 field EPSPs. In the present experiments, similar applications of 3-O-methyl-D-glucose, which is also taken up by cells but is not phosphorylated, had only a weak blocking action and elicited no potentiation. Possible explanations for the marked effects of 2-DG include a more rapid block of glycolysis and the production of phosphorylated derivatives of 2-DG.
Starting Page	250
Ending Page	252
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(01)02077-7
PubMed reference number	11259785
Journal	Medline
Volume Number	895
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899301020777
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899301020777?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2801%2902077-7
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article