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Expression of the interleukin-21 and phosphorylated extracellular signal regulated kinase 1/2 in Kimura disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, Qiuqiang Li, Chen-xi Shao, Bo Quan Gong, Zhong-cheng Liu, Hui Ling, Bin Abasi, Keremu Hu, Lu-lu Wang, Bing Wei Yin, Xiao-peng |
| Copyright Year | 2017 |
| Abstract | OBJECTIVE To investigate the expressions of interleukin (IL)-21 and phosphorylated extracellular signal regulated kinase 1/2 (pERK1/2) in Kimura disease (KD) and to correlate the findings with clinical and prognostic variables. METHODS Immunohistochemical analysis of IL-21 and pERK1/2 was performed in 18 cases of KD and five gender- and age-matched control samples. Clinical data were extracted and patients followed up for a mean period of 32.1 months. RESULTS After a mean follow-up period of 32.1 months (range 1-102 months), recurrence was diagnosed as the end point for seven patients-that is, a 44% (7/16) cumulative recurrence rate. In comparison with gender- and age-matched controls, patients showed strong in situ expressions of IL-21 and pERK1/2, respectively (p<0.05). Patients with strong IL-21 staining intensity and overexpression of pERK1/2 had a lower recurrence rate than those with moderate staining intensity (p=0.049, p=0.019, respectively). However, differences were not statistically significant by gender, age, eosinophils, location, multiplicity, laterality, size, duration and primary outbreak. pERK1/2 was the independent prognostic factor (p=0.020), while age, gender, eosinophils, multiplicity, laterality, size, duration, primary outbreak and expression of IL-21 were not. CONCLUSIONS This study suggests that the IL-21/pERK1/2 pathway is activated in KD, and pERK1/2 might be considered as a potential prognostic indicator in KD. |
| Starting Page | 684 |
| Ending Page | 689 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28108473v1 |
| Alternate Webpage(s) | https://doi.org/10.1136/jclinpath-2016-204096 |
| DOI | 10.1136/jclinpath-2016-204096 |
| Journal | Journal of clinical pathology |
| Volume Number | 70 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Eosinophil count procedure Extraction Follow-Up Report Handedness IL22 wt Allele Interleukins Kimura Disease Patients Prognostic Factors Staining Intensity Staining method interleukin-21 |
| Content Type | Text |
| Resource Type | Article |
