NDLI: Invasive Species Management on Military Lands: Clustered Regularly Interspaced Short Palindromic Repeat/ CRISPR associated protein 9 (CRISPR/Cas9) based Gene Drives

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Invasive Species Management on Military Lands: Clustered Regularly Interspaced Short Palindromic Repeat/ CRISPR associated protein 9 (CRISPR/Cas9) based Gene Drives

Content Provider	Semantic Scholar
Author	Gong, Ping
Copyright Year	2017
Abstract	Abstract : Applications of genetic engineering-based technologies to the control of invasive species are emerging as an important area of innovation. As a mechanism to spread the desired genes and associated traits into the tar-get population, gene drive is recognized as a promising genetic biocontrol strategy to combat invasive species. Unlike existing technologies that de-pend on the cumbersome custom-making of new proteins for each DNA target, the CRISPR system uses RNA as its DNA-homing mechanism, which makes it low cost, high efficiency, easy to implement, and dramatically shortens the design-build-test cycle for gene drive development. The CRISPR/Cas9 technology can alter multiple loci at the target gene that prevent mutations from blocking the spread of the drive. It can also be used to develop multiple types of gene drives such as precision, immunization, and reversal drives to precisely target a specific subpopulation, protect a population from any future gene drive invasions, and overwrite previously released drives in case of unanticipated effects, respectively. Poised to become a self-sustaining, highly efficient, environmentally benign, and cost-effective alternative for invasive species control, CRISPR/Cas9-mediated gene drives can sweep a deleterious gene through a population exponentially faster than the normal Mendelian in-heritance, and thus suppress or eradicate the target invasive species.
File Format	PDF HTM / HTML
DOI	10.21079/11681/22721
Alternate Webpage(s)	http://www.dtic.mil/dtic/tr/fulltext/u2/1035990.pdf
Alternate Webpage(s)	https://doi.org/10.21079/11681%2F22721
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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