NDLI: In situ aqueous synthesis of genetically engineered polypeptide-capped Ag2S quantum dots for second near-infrared fluorescence/photoacoustic imaging and photothermal therapy.

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In situ aqueous synthesis of genetically engineered polypeptide-capped Ag2S quantum dots for second near-infrared fluorescence/photoacoustic imaging and photothermal therapy.

Content Provider	Semantic Scholar
Author	Zhao, Dong-Hui Yang, Xiaoquan Hou, Xiao-Lin Xuan, Yang Song, Xian-Lin Zhao, Yuan-Di Chen, Wei Wang, Qiong
Copyright Year	2019
Abstract	Ag2S quantum dots have received extensive attention as theranostic agents for second near-infrared (NIR-II) fluorescence and photoacoustic dual-mode imaging, and photothermal therapy. However, it is still greatly challenging to synthesize Ag2S quantum dots using aqueous synthesis. In this study, genetically engineered polypeptide-capped Ag2S quantum dots were successfully synthesized. Three cysteines were integrated to the C-terminal and N-terminal of RGDPC10A to enhance the stability and brightness of the synthesized Ag2S quantum dots. The RGDPC10A-capped Ag2S quantum dots exhibited excellent stability, outstanding resistance to photobleaching, and a superior quantum yield of up to 3.78% in the NIR-II biological window. The in vitro and in vivo results showed that the RGDPC10A-capped Ag2S quantum dots possessed typical NIR-II fluorescence, photoacoustic imaging, and photothermal therapeutic effectiveness against tumors. Moreover, the results of toxicity assays suggested that the RGDPC10A-capped Ag2S quantum dots have negligible long-term toxicity. These findings open up the possibility for synthesizing theranostic agents by using this aqueous method.
Starting Page	2484
Ending Page	2492
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1039/C8TB03043J
PubMed reference number	32255125
Journal	Medline
Volume Number	7
Issue Number	15
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/tb/c8tb03043j/c8tb03043j1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C8TB03043J
Journal	Journal of materials chemistry. B
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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