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Macrotheranostic Probe with Disease-Activated Near-Infrared Fluorescence, Photoacoustic, and Photothermal Signals for Imaging-Guided Therapy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhen, Xu Zhang, Jianjian Huang, Jiaguo Xie, Chen Miao, Qingqing Pu, Kanyi |
| Copyright Year | 2018 |
| Abstract | Theranostics provides opportunities for precision cancer therapy. However, theranostic probes that simultaneously turn on their diagnostic signal and pharmacological action only in respond to a targeted biomarker have been less exploited. We herein report the synthesis of a macrotheranostic probe that specifically activates its near-infrared fluorescence (NIRF), photoacoustic (PA), and photothermal signals in the presence of a cancer-overexpressed enzyme for imaging-guided cancer therapy. Superior to the small-molecule counterpart probe, the macrotheranostic probe has ideal biodistribution and renal clearance, permitting passive targeting of tumors, in situ activation of multimodal signals, and effective photothermal ablation. Our study thus provides a macromolecular approach towards activatable multimodal phototheranostics. |
| Starting Page | 7804 |
| Ending Page | 7808 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/anie.201803321 |
| PubMed reference number | 29665259 |
| Journal | Medline |
| Volume Number | 57 |
| Issue Number | 26 |
| Alternate Webpage(s) | http://pdf.xuebalib.com:1262/62nogDxl5rCN.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/anie.201803321 |
| Journal | Angewandte Chemie |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
