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The role of the gastrointestinal tract in phosphate homeostasis in health and chronic kidney disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Marks, Joanne Debnam, Edward S. Unwin, Robert J. |
| Copyright Year | 2013 |
| Abstract | PURPOSE OF REVIEW For a number of years, there has been increasing interest in the concept of directly targeting intestinal phosphate transport to control hyperphosphatemia in chronic kidney disease. However, progress has been slow due to the paucity of information on the mechanisms involved in intestinal phosphate absorption. This editorial highlights the most recent developments in our understanding of this process and the role of the intestine in the maintenance of phosphate balance. RECENT FINDINGS Recent studies in NaPi-IIb knockout mice have confirmed that this transport protein plays a significant role in intestinal phosphate absorption and is critical in the proposed feed-forward mechanism between the small intestine and kidney, which helps to maintain normal phosphate balance and steady-state plasma phosphate concentrations. In addition, renal failure-induced hyperphosphatemia is attenuated in NaPi-IIb knockout mice, confirming that NaPi-IIb is a suitable target in the prevention and treatment of hyperphosphatemia. SUMMARY Recent findings suggest that consumption of processed foods containing phosphate preservatives may lead to excessive phosphate exposure (if not overload), toxicity, and cardiovascular disease in the general population, as well as in patients with declining renal function. Therefore, establishing more effective ways of targeting the intestine to limit dietary phosphate absorption could have wide-reaching health benefits. |
| Starting Page | 481 |
| Ending Page | 487 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1097/MNH.0b013e3283621310 |
| PubMed reference number | 23666413 |
| Journal | Medline |
| Volume Number | 22 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/67/bf/conhy-22-481.PMC4196778.pdf |
| Alternate Webpage(s) | http://discovery.ucl.ac.uk/1393792/1/The_role_of_the_gastrointestinal_tract_in.18.pdf |
| Alternate Webpage(s) | https://doi.org/10.1097/MNH.0b013e3283621310 |
| Journal | Current opinion in nephrology and hypertension |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
