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The role of the gastrointestinal tract in phosphate homeostasis in health and chronic kidney disease
| Content Provider | Scilit |
|---|---|
| Author | Marks, Joanne Debnam, Edward S. Unwin, Robert J. |
| Copyright Year | 2013 |
| Description | Journal: Current opinion in nephrology and hypertension For a number of years, there has been increasing interest in the concept of directly targeting intestinal phosphate transport to control hyperphosphatemia in chronic kidney disease. However, progress has been slow due to the paucity of information on the mechanisms involved in intestinal phosphate absorption. This editorial highlights the most recent developments in our understanding of this process and the role of the intestine in the maintenance of phosphate balance. Recent studies in NaPi-IIb knockout mice have confirmed that this transport protein plays a significant role in intestinal phosphate absorption and is critical in the proposed feed-forward mechanism between the small intestine and kidney, which helps to maintain normal phosphate balance and steady-state plasma phosphate concentrations. In addition, renal failure-induced hyperphosphatemia is attenuated in NaPi-IIb knockout mice, confirming that NaPi-IIb is a suitable target in the prevention and treatment of hyperphosphatemia. Recent findings suggest that consumption of processed foods containing phosphate preservatives may lead to excessive phosphate exposure (if not overload), toxicity, and cardiovascular disease in the general population, as well as in patients with declining renal function. Therefore, establishing more effective ways of targeting the intestine to limit dietary phosphate absorption could have wide-reaching health benefits. |
| Related Links | http://europepmc.org/articles/pmc4196778?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196778/pdf |
| Ending Page | 487 |
| Page Count | 7 |
| Starting Page | 481 |
| ISSN | 10624821 |
| e-ISSN | 14736543 |
| DOI | 10.1097/mnh.0b013e3283621310 |
| Journal | Current opinion in nephrology and hypertension |
| Issue Number | 4 |
| Volume Number | 22 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2013-07-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current opinion in nephrology and hypertension Chronic Kidney Disease Phosphate Toxicity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Nephrology |
