Loading...
Please wait, while we are loading the content...
Similar Documents
Assessment of blinding in clinical trials.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bang, Heejung Ni, Liyun Davis, Clarence E. |
| Copyright Year | 2004 |
| Abstract | Success of blinding is a fundamental issue in many clinical trials. The validity of a trial may be questioned if this important assumption is violated. Although thousands of ostensibly double-blind trials are conducted annually and investigators acknowledge the importance of blinding, attempts to measure the effectiveness of blinding are rarely discussed. Several published papers proposed ways to evaluate the success of blinding, but none of the methods are commonly used or regarded as standard. This paper investigates a new approach to assess the success of blinding in clinical trials. The blinding index proposed is scaled to an interval of -1 to 1, 1 being complete lack of blinding, 0 being consistent with perfect blinding and -1 indicating opposite guessing which may be related to unblinding. It has the ability to detect a relatively low degree of blinding, response bias and different behaviors in two arms. The proposed method is applied to a clinical trial of cholesterol-lowering medication in a group of elderly people. |
| Starting Page | 1032 |
| Ending Page | 1038 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.cscc.unc.edu/codi/othdocs/OPERCOMMArticleaboutblindinginclinicaltrials02152010.pdf |
| PubMed reference number | 15020033v1 |
| Volume Number | 25 |
| Issue Number | 2 |
| Journal | Controlled clinical trials |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alveolar rhabdomyosarcoma Behavior Cholesterol Paper Scientific Publication Subject Unblinding Event Record |
| Content Type | Text |
| Resource Type | Article |
