Average versus highest intraocular pressure analyses in glaucoma clinical trials.

Content Provider	Semantic Scholar
Author	DeMill, David L. Wirostko, Barbara M. Nelson, Lindsay A. Stewart, Jeanette A. Stewart, William C.
Copyright Year	2013
Abstract	PURPOSE To evaluate methods which account for both eyes as a single, independent variable in glaucoma clinical trials. METHODS A review of clinical trial articles published between January 1995 and April 2011 evaluating currently used topical glaucoma medications. RESULTS This analysis included 17 articles with 36 treatment arms of which 14 were prostaglandins, 13 β-blockers, 6 topical carbonic anhydrase inhibitors and 3 α-agonists. Twenty-four articles used average intraocular pressure (IOP) analysis, 12 used the highest IOP analysis and none utilized the randomized eye method. At untreated baseline, there was a difference in the IOP between average IOP and highest baseline IOP analyses at 8 a.m. (p = 0.001) and for the diurnal curve (p = 0.02) as well as specifically for β-blockers (p = 0.002) at 8 a.m. and β-blockers for the diurnal curve (p = 0.01). CONCLUSIONS This study suggests that the highest IOP analysis method generally provides slightly higher IOPs at baseline than the average IOP analysis method.
Starting Page	49
Ending Page	51
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.prnorb.com/wp-content/uploads/2013/01/CV-400-Avg-vs-High-Oph-Res.pdf
PubMed reference number	23128328v1
Alternate Webpage(s)	https://doi.org/10.1159/000343773
DOI	10.1159/000343773
Journal	Ophthalmic research
Volume Number	49
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	Alveolar rhabdomyosarcoma Eye Glaucoma Physiologic Intraocular Pressure Prostaglandins Scientific Publication Structure of both eyes
Content Type	Text
Resource Type	Article