NDLI: Does the eosinophil have a protective role in amebiasis?

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Does the eosinophil have a protective role in amebiasis?

Content Provider	Semantic Scholar
Author	López-Osuna, Martha Velazquez, Juan R. Kretschmer, Roberto R.
Copyright Year	1997
Abstract	While normal human eosinophils are destroyed in vitro by virulent Entamoeba histolytica, notwithstanding the presence of antibodies and complement, activated eosinophils promptly destroy the parasite although dying also at the end of the process. To study the possible in vivo participation of eosinophils in invasive amebiasis, we compared the induction of experimental amebic abscess of the liver (AAL) in gerbils (Meriones unguiculatus) previously made eosinophilic through Toxocara canis antigen injection and in normal control gerbils. After intraportal inoculation of 10(5) ameba trophozoites (6 and 24 hr), the ratio of gerbils with AAL, as well as the number and size of the microabscesses was comparable in eosinophilic and control gerbils. However, at 96 hr the number and size of the microabscesses were significantly smaller (p < 0.05) in eosinophilic gerbils. On the other hand the actuarial AAL survival curve up to 45 days post-amebic inoculation was significantly (p < 0.05) shifted to the right in controls. These results suggest that antigen-induced eosinophilia may exert a protective effect against AAL in gerbils.
Starting Page	683
Ending Page	704
Page Count	22
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/mioc/v92s2/v92s2a33.pdf
PubMed reference number	9698942v1
Volume Number	92
Journal	Memorias do Instituto Oswaldo Cruz
Language	English
Access Restriction	Open
Subject Keyword	Amebic colitis Amoeba genus Amoeba identified:Prid:Pt:Asp:Nom:Iron hematoxylin stain Complement System Proteins Eosinophilia Eosinophilic Granuloma Gerbils Mongolian gerbil skin allergenic extract 20000 UNT/ML Injectable Solution Sarcodina Small Toxocara canis Trophozoite eosinophil
Content Type	Text
Resource Type	Article

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