NDLI: Proton T1 relaxation times of metabolites in human occipital white and gray matter at 7 T.

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Proton T1 relaxation times of metabolites in human occipital white and gray matter at 7 T.

Content Provider	Semantic Scholar
Author	Xin, Lijing Schaller, Benoît Mlynarik, Vladimir Lu, Huanxiang Gruetter, Rolf
Copyright Year	2013
Abstract	Proton T1 relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T1 values of CH3 and CH2 group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in occipital white matter and gray matter at 7 T using an inversion-recovery technique combined with a newly implemented semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence (echo time = 12 ms). The mean T1 values of metabolites in occipital white matter and gray matter ranged from 0.9 to 2.2 s. Among them, the T1 of glutathione, scyllo-inositol, taurine, phosphorylethanolamine, and N-acetylaspartylglutamate were determined for the first time in the human brain. Significant differences in T1 between white matter and gray matter were found for water (-28%), total choline (-14%), N-acetylaspartylglutamate (-29%), N-acetylaspartate (+4%), and glutamate (+8%). An increasing trend in T1 was observed when compared with previously reported values of N-acetylaspartate (CH3 ), total creatine (CH3 ), and total choline at 3 T. However, for N-acetylaspartate (CH3 ), total creatine, and total choline, no substantial differences compared to previously reported values at 9.4 T were discernible. The T1 values reported here will be useful for the quantification of metabolites and signal-to-noise optimization in human brain at 7 T.
Starting Page	915
Ending Page	920
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://infoscience.epfl.ch/record/182826/files/Xin_T1_7T_2012.pdf
Alternate Webpage(s)	http://infoscience.epfl.ch/record/182826/files/Xin_T1_7T_2012.pdf
PubMed reference number	22648904v1
Alternate Webpage(s)	https://doi.org/10.1002/mrm.24352
DOI	10.1002/mrm.24352
Journal	Magnetic resonance in medicine
Volume Number	69
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Choline Creatine Glutamate Carboxypeptidase II Glutamic Acid Glutathione Gray Matter Inositol Metabolite N-acetylaspartate Protons Quantitation Scientific Publication Taurine White matter phosphoethanolamine scyllitol
Content Type	Text
Resource Type	Article

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