NDLI: Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1.

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Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1.

Content Provider	Semantic Scholar
Author	Yilmaz, Alper Bolinger, Cheryl Boris-Lawrie, Kathleen
Copyright Year	2006
Abstract	Human immunodeficiency virus type 1 (HIV-1) has a small, multifunctional genome that encodes a relatively large and complex proteome. The virus has adopted specialized post-transcriptional control mechanisms to maximize its coding capacity while economically maintaining the information stored in cis-acting replication sequences. The conserved features of the 5' untranslated region of all viral transcripts suggest they are poor substrates for cap-dependent ribosome scanning and provide a compelling rationale for internal initiation of translation. This article summarizes key experimental results of studies that have evaluated HIV-1 translation initiation. A model is discussed in which cap-dependent and cap-independent initiation mechanisms of HIV-1 co-exist to ensure viral protein production in the context of 1) structured replication motifs that inhibit ribosome scanning, and 2) alterations in host translation machinery in response to HIV-1 infection or other cellular stresses. We discuss key issues that remain to be understood and suggest parameters to validate internal initiation activity in HIV-1 and other retroviruses.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.benthamscience.com/chivr/openaccessarticles/chivr4-2/002AB.pdf
PubMed reference number	16611053v1
Volume Number	4
Issue Number	2
Journal	Current HIV research
Language	English
Access Restriction	Open
Subject Keyword	5' Untranslated Regions Entity Name Part Qualifier - adopted Genetic Translation Process HIV Infections HIV-1 Immunologic Deficiency Syndromes Post-Transcriptional Regulation Proteome Ribosomes Transcript Transcription Initiation Transcription, Genetic Transcriptional Regulation Translation Initiation Viral Proteins
Content Type	Text
Resource Type	Article

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