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IL-6 and its signalling in atherosclerosis 216 Diversity of the IL-6 / gp 130 signalling
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schuett, Harald Luchtefeld, Maren Grothusen, Christina Grote, Karsten Schieffer, Bernhard |
| Copyright Year | 2017 |
| Abstract | The importance of inflammation as a driver of pathology is no longer confined to autoimmune and infectious diseases. In line with convincing experimental data as well as abundant clinical findings the current view of atherosclerosis points to inflammation as a critical regulator of atherosclerotic plaque formation and progression leading to the fatal clinical endpoints myocardial infarction, stroke or sudden cardiac death. The underlying mechanisms have been a matter of intense research during the last decades. In this regard, the interleukin-6 (IL-6) cytokines and their signalling events have been shown to contribute to both, atherosclerotic plaque development and plaque destabilisation via a variety of mechanisms. These involve the release of other pro-inflammatory cytokines, oxidation of lipopro- |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://th.schattauer.de/en/contents/archive/issue/946/manuscript/11655/download.html |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
