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Biomimetic characteristics of mussel adhesive protein-loaded collagen membrane in guided bone regeneration of rabbit calvarial defects
| Content Provider | Semantic Scholar |
|---|---|
| Author | Song, Woong-Kyu Kang, Joo-Hyun Cha, Jae-Kook Lee, Jung-Seok Paik, Jeong-Won Jung, Ui-Won Kim, Byung-Hoon Choi, Seong-Ho |
| Copyright Year | 2018 |
| Abstract | Purpose The aim of the present study was to evaluate the biocompatibility and barrier function of mussel adhesive protein (MAP)-loaded collagen membranes in guided bone regeneration (GBR). Methods Eight male New Zealand white rabbits were used. Four circular defects (diameter: 8 mm) were created in the calvarium of each animal. The defects were randomly assigned to 1) a negative control group, 2) a cyanoacrylate (CA)-loaded collagen membrane group (the CA group), 3) a MAP-loaded collagen membrane group (the MAP group), and 4) a group that received a polycaprolactone block with MAP-loaded collagen membrane (the MAP-PCL group). Specimens were harvested at 2 weeks (n=4) and 8 weeks (n=4) postoperatively for observational histology and histometric analysis. Results In the histologic analysis, MAP was completely absorbed without any byproducts. In contrast, some of the CA adhesive remained, showing an inflammatory reaction, at 8 weeks. In the MAP-PCL group, the MAP-loaded collagen membranes served as a barrier membrane despite their fast degradation in GBR. No significant difference was found in the amount of new bone between the MAP-PCL and MAP groups (1.82±0.86 mm2 and 2.60±0.65 mm2, respectively). Conclusions The MAP-loaded collagen membrane functioned efficiently in this rabbit calvarial GBR model, with excellent biocompatibility. Further research is needed to assess clinical applications in defect types that are more challenging for GBR than those used in the current model. |
| Starting Page | 305 |
| Ending Page | 316 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.5051/jpis.2018.48.5.305 |
| PubMed reference number | 30405938 |
| Journal | Medline |
| Volume Number | 48 |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/79/jpis-48-305.PMC6207793.pdf |
| Alternate Webpage(s) | https://www.jpis.org/Synapse/Data/PDFData/1150JPIS/jpis-48-305.pdf |
| Alternate Webpage(s) | https://doi.org/10.5051/jpis.2018.48.5.305 |
| Journal | Journal of periodontal & implant science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
