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Treatment-responsiveness of Negative Symptoms in Schizophrenia: a Double-blind Placebo-control Clinical Trial
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shafti, Saeed Shoja |
| Copyright Year | 2006 |
| Abstract | Background: The negative symptoms of schizophrenia remain a major clinical challenge. Nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. The aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia. Methods: This study is a six-week randomized placebocontrol trial of nortriptyline or placebo as an adjunctive to haloperidol (5 mg) in the treatment of 50 patients with Diagnostic and statistical manual for Mental Disorders (DSM-IV) criteria for chronic schizophrenia. Result: The primary finding of the trial was a significant reduction in Scale for Assessment of Negative Symptoms (SANS) in the nortriptyline group compared to placebo at the end of 6 week. All the subscales of SANS demonstrate significant improvement. Conclusion: This study suggests a potential role for nortriptyline in the treatment of negative symptoms of schizophrenia. Iran J Med Sci 2006; 31(3): 135-138. |
| Starting Page | 135 |
| Ending Page | 138 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Volume Number | 31 |
| Alternate Webpage(s) | http://www.sid.ir/en/VEWSSID/J_pdf/85120060304.pdf |
| Alternate Webpage(s) | http://ijms.sums.ac.ir/index.php/IJMS/article/download/2161/647 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
