NDLI: Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia

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Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia

Content Provider	Scilit
Author	Heresco-Levy, Uriel Javitt, Daniel C. Ermilov, Marina Silipo, Gail Shimoni, Jonathan
Copyright Year	1998
Description	Dysfunction of N-methyl-d-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission may be relevant to the pathogenesis of negative symptoms in schizophrenia. The tuberculostatic compound d-cycloserine (DCS) acts as a partial agonist at the strychnine-insensitive glycine regulatory site on the NMDA receptor complex. Dose-finding trials suggest that DCS doses of 50–100 mg/d may be beneficial in the treatment of negative symptoms in schizophrenia. Nine treatment-resistant chronic schizophrenic patients participated in a double-blind, placebo-controlled, adjuvant treatment trial with 50 mg/d DCS. Between treatment-groups differences in symptom changes were not significant. However, a significant (p < 0.05) reduction in negative symptoms was registered during treatment with DCS but not placebo. Greater reductions were registered in patients with lower baseline serum glycine levels (p < 0.008). No side effects were registered. These preliminary findings indicate a potential role of DCS in the treatment of negative symptoms in schizophrenia. However, the degree of symptom reduction may be modest, at least among treatment-resistant inpatients.
Related Links	https://academic.oup.com/ijnp/article-pdf/1/2/131/1992797/1-2-131.pdf
Ending Page	135
Page Count	5
Starting Page	131
DOI	10.1017/S1461145798001242
Journal	International Journal of Neuropsychopharmacology
Issue Number	2
Volume Number	1
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	1998-12-01
Access Restriction	Open
Subject Keyword	International Journal of Neuropsychopharmacology Clinical Psychology Negative Symptoms in Schizophrenia
Content Type	Text
Resource Type	Article

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