NDLI: UvA-DARE ( Digital Academic Repository ) Vascular dysfunction in preeclampsia

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UvA-DARE ( Digital Academic Repository ) Vascular dysfunction in preeclampsia

Content Provider	Semantic Scholar
Author	Wijk, Marjaa J. Van Nieuwland, Rienk Kublickiene, Karolina R.
Copyright Year	2017
Abstract	t Objective:: To determine whether the phospholipi d composition of circulating microparticles fromm women with preeclampsia , normal pregnant and nonpregnan t women and to establish their effectt on endothelial function in isolated myometrial arteries from normal pregnant women. Methods:: Plasma samples were collected from women with preeclampsi a (n=ll), normal pregnantt (n-10) and nonpregnan t women (n=10), matched for age and gestationa l age. The phospholipi dd composition of the microparticles was determined by high performanc e thin layer chromatography .. Myometrial resistanc e arteries were isolated from myometrial biopsies at cesarea nn delivery of normal pregnant women and mounted in a wire myograph after overnight incubationn with isolated microparticles from women with preeclampsia , normal pregnant and nonpregnan tt women. BK-mediated relaxation was determined. Results:: Microparticles in all groups mainly consisted of PC and smaller amount s of SM, PEa, PI andd lyso-phospholipids . The percentag e lyso-PC was significantl y decrease d in pregnanc y and preeclampsia .. There were no major differences in phospholipi d composition between women withh preeclampsi a and normal pregnant women. BK-mediated relaxation was significantl y decrease dd in myometrial arteries after incubation with preeclampti c microparticles, in contrast to normall pregnant and nonpregnan t microparticles . Conclusions:: Circulating microparticles from women with preeclampsi a diminish endotheliumdependen tt relaxation after overnight incubation in isolated myometrial arteries. This difference doess not seem to resul t from differences in the phospholipi d composition of circulating microparticles. .
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://pure.uva.nl/ws/files/3483107/32906_UBA002001210_14.pdf
Alternate Webpage(s)	https://pure.uva.nl/ws/files/3483095/32900_UBA002001210_08.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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