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Sirolimus-eluting stent for the treatment of in-stent restenosis: a quantitative coronary angiography and three-dimensional intravascular ultrasound study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sousa, Jose Eduardo M. Costa, Marco A. Abizaid, Alexandre Antônio Cunha Sousa, Amanda Guerra De Moraes Rego Feres, Fausto Mattos, Luiz Alberto Piva Centemero, Marinella Patrizia Maldonado, Galo Abizaid, Andrea C. Pinto, Ibraim M. F. Falotico, Robert Jaeger, Judith Popma, Jeffrey J. Serruys, Patrick W. |
| Copyright Year | 2003 |
| Abstract | BACKGROUND We have previously reported the safety and effectiveness of sirolimus-eluting stents for the treatment of de novo coronary lesions. The present investigation explored the potential of this technology to treat in-stent restenosis. METHODS AND RESULTS Twenty-five patients with in-stent restenosis were successfully treated with the implantation of 1 or 2 sirolimus-eluting Bx VELOCITY stents in São Paulo, Brazil. Nine patients received 2 stents (1.4 stents per lesion). Angiographic and volumetric intravascular ultrasound (IVUS) images were obtained after the procedure and at 4 and 12 months. All vessels were patent at the time of 12-month angiography. Angiographic late loss averaged 0.07+/-0.2 mm in-stent and -0.05+/-0.3 mm in-lesion at 4 months, and 0.36+/-0.46 mm in-stent and 0.16+/-0.42 mm in-lesion after 12 months. No patient had in-stent or stent margin restenosis at 4 months, and only one patient developed in-stent restenosis at 1-year follow-up. Intimal hyperplasia by 3-dimensional IVUS was 0.92+/-1.9 mm(3) at 4 months and 2.55+/-4.9 mm(3) after 1 year. Percent volume obstruction was 0.81+/-1.7% and 1.76+/-3.4% at the 4- and 12-month follow-up, respectively. There was no evidence of stent malapposition either acutely or in the follow-up IVUS images, and there were no deaths, stent thromboses, or repeat revascularizations. CONCLUSION This study demonstrates the safety and the potential utility of sirolimus-eluting Bx VELOCITY stents for the treatment of in-stent restenosis. |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/01.CIR.0000047063.22006.41 |
| PubMed reference number | 12515737 |
| Journal | Medline |
| Volume Number | 107 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/107/1/24.full.pdf |
| Alternate Webpage(s) | http://www.summitmd.com/pdf/pdf/060630_lec6.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/107/1/24.full.pdf?download=true |
| Alternate Webpage(s) | https://repub.eur.nl/pub/10045/12515737.pdf |
| Alternate Webpage(s) | https://doi.org/10.1161/01.CIR.0000047063.22006.41 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Biography |
