NDLI: Expresión de p16INK4a en biopsias de cérvix uterino. Utilidad en el diagnóstico diferencial entre cervicitis crónica reactiva, neoplasia intraepitelial cervical de bajo y alto grado y carcinoma invasor

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Expresión de p16INK4a en biopsias de cérvix uterino. Utilidad en el diagnóstico diferencial entre cervicitis crónica reactiva, neoplasia intraepitelial cervical de bajo y alto grado y carcinoma invasor

Content Provider	Semantic Scholar
Author	Patzi, Ana Marcela Cañedo Vázquez, Avissaí Alcántara Hidalgo, Carlos Ortíz
Copyright Year	2006
Abstract	La morbimortalidad por carcinoma de cervix uterino ha disminuido gracias a la citologia cervicovaginal que detecta lesiones cervicales tempranas. Sin embargo, el indice de falsos positivos y negativos, asi como la falta de reproducibilidad intra e interobservador en el diagnostico de neoplasia intraepitelial cervical han llevado a investigar marcadores objetivos para la identificacion de celulas displasicas. p16INK4a es un producto del gen p16, que ha demostrado ser util en distinguir celulas neoplasicas de celulas reactivas. Estudiamos 65 biopsias de cervix con diagnosticos de cervicitis cronica en seis, lesion intraepitelial de bajo grado en 15, lesion intraepitelial de alto grado en 28 (15 NIC II y 13 NIC III), carcinoma epidermoide in situ en dos y carcinoma invasor en 14. Nuestros resultados demostraron relacion directa entre la sobreexpresion de p16INK4a mediante inmunohistoquimica, y el grado de lesion neoplasica. Novena y dos por ciento de carcinomas invasores, 100% de carcinomas in situ y 100% de lesiones intraepiteliales de alto grado expresaron p16. Todos los cervix reactivos fueron negativos al p16. Del grupo de lesiones intraepiteliales cervicales de bajo grado, solo 33.33% fueron positivas a p16. Estos hallazgos confirman la utilidad de p16INK4a para distinguir cervix reactivo de lesiones intraepiteliales de alto grado.
Starting Page	49
Ending Page	57
Page Count	9
File Format	PDF HTM / HTML
Volume Number	51
Alternate Webpage(s)	http://www.medigraphic.com/pdfs/abc/bc-2006/bc062b.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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