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Risk factors for human herpesvirus 8 infection among adults in the United States and evidence for sexual transmission.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mcquillan, Geraldine M. Mbisa, Georgina L. Cohn, Silvia E. Whitby, Denise Goedert, James J. |
| Copyright Year | 2007 |
| Abstract | BACKGROUND Human herpesvirus 8 (HHV-8) causes Kaposi sarcoma. In the United States, transmission routes for HHV-8 are uncertain. METHODS The National Health and Nutrition Examination Survey III sampled individuals from the US general population (1988-1994). We used enzyme immunoassays (EIAs) to measure HHV-8 antibodies (K8.1 and open reading frame [ORF] 73 antigens) in 13,894 surveyed adults. HHV-8 seroprevalence was examined according to sexual history and viral coinfection markers. RESULTS Overall, seroprevalence was low when a highly specific cutoff was used (K8.1, 1.6%; ORF73, 1.5%) but was higher when a less-specific cutoff was used (K8.1, 7.1%; ORF73, 7.4%). When the more-specific approach was used, K8.1 seroprevalence was similar in men and women. Men who have sex with men (MSM) had a higher K8.1 seroprevalence (8.2%). Among other men, K8.1 seroprevalence was marginally associated with duration of heterosexual activity (P=.1) and was positively associated with the lifetime number of sex partners (P=.04) and with coinfections with hepatitis B virus (6.1% vs. 1.2% without coinfection; P<.001) and herpes simplex virus 2 (2.7% vs. 1.0%; P=.003). Among women, K8.1 seroprevalence was not significantly related to duration of sexual activity, the lifetime number of sex partners, or viral coinfections. The ORF73 EIA revealed similar but less clear-cut patterns. CONCLUSIONS Among men, HHV-8 transmission may occur through sexual activity, particularly sex with other men. No evidence was observed for heterosexual transmission to women. |
| Starting Page | 199 |
| Ending Page | 207 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://watermark.silverchair.com/196-2-199.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAhQwggIQBgkqhkiG9w0BBwagggIBMIIB_QIBADCCAfYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMrm8-Wqx6bBu600S0AgEQgIIBx9y4-v6QI9cxq74FhKgsxcCz1cOKSu9SngjvnVnQBkQHgG7Ag7GaShuT9z3Top1UWXw8EdQkqYNs50cTM3PbVSFx5SHsYpjUf4LcdPTz0_RINbpatoTYl2kkBthto6KqPgcnR0xZ8DB5iyKmS0hzgUmRf-TmyMCI4_WW69xWobxQwYLBK0S-NJ6DM4Cqkay2IA4rDi-rz04fbqdlfZgCfZC37BB4GdQkMYGB0xeG9DAv9LtoIn0JZ3r7NnFqQX3FgiY4TnEsvEPsHiYl-iTHn13XuLX3hZdxHwaWQRO_YK5IO93C9fHscdcn45Kytbjly-80UtKoi9HODM3V955BjUMlSaNmUxVxIc6pgBBD5Zv7XxK7gw-dwAlUSTUS1vrj40OymeSwVeEitSRsDed7iBruTdLmRI2REli-q4MdQoqpUe1GXv15oXKIDNoo0zfwIQlBLruqIUSdiEl6NHfVBncUdOgHqF7vs7mLGk3u6xFVJbHq8vxb1lD5_do7H3dDJMMG413vrAThPVBBxyXg7zE5jgpvos6aVb7ifOtqq5VeNpzsUp6RSMEpN9MlXXA3_-oz5WjtEBTEwOIMXl8yiKw5g7OyBkaB |
| PubMed reference number | 17570106v1 |
| Volume Number | 196 |
| Issue Number | 2 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Coinfection Enzyme Immunoassay HHV8 ORF73 Gene Hepatitis B Virus Herpes Simplex Infections Herpesvirus 1, Cercopithecine Human Herpes Virus 8 Infection Immunoassay method Open Reading Frames Reading Frames (Nucleotide Sequence) Sex Behavior Virus Diseases human herpesvirus 8 |
| Content Type | Text |
| Resource Type | Article |
