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Effects of intracranial self-stimulation on acetylcholine efflux in rat ventral tegmental area, nucleus accumbens and medial prefrontal cortex
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nakamura, Masato Nakahara, Daiichiro |
| Copyright Year | 1998 |
| Abstract | Intracranial self-stimulation (ICSS) of the medial forebrain bundle (MFB) activates, in the first place, the descending myelinated fibers, synapsing to cholinergic neurons of pedunculopontine tegmental nucleus which project on dopaminergic neurons of the ventral tegmental area (VTA). Thus, ascending dopaminergic pathway is transsynaptically activated to release dopamine in its terminals such as the nucleus accumbens (NAC) and medial prefrontal cortex (mPFC), both of which also receive cholinergic innervations, In the present study, microdialysts was used to examine changes of extracellular acetylcholine (ACh) levels in the rat VTA, NAC and mPFC following ICSS of the MFB. Baseline levels of ACh were 10.2 fmol/M ~1 in the mPFC and undetectable in the VTA and NAC. In the mPFC, ACh efflux increased to a maximum of 222% of baseline during ICSS and returned to baseline soon after ICSS was terminated. On the other hand, in the presence of an acetylcholinesterase inhibitor, ACh efflux increased to a maximum of 334% of baseline in the VTA and 184% m the NAC immediately after the start of ICSS and remained elevated during the experiment. The result suggests a diffuse activation of central cholinergic systems during ICSS of the MFB. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0168-0102(98)82142-1 |
| Volume Number | 31 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0168010298821421 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0168010298821421?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0168-0102%2898%2982142-1 |
| Journal | Neuroscience Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
