Comparative effects of neurotensin, neurotensin(8-13) and [D-Tyr11]neurotensin applied into the ventral tegmental area on extracellular dopamine in the rat prefrontal cortex and nucleus accumbens

Content Provider	Semantic Scholar
Author	Sotty, Florence Brun, Philippe Leonetti, Maud Steinberg, Régis Suaud-Chagny, M. F.
Copyright Year	2000
Abstract	Ejections of 10(-5)-10(-3)M neurotensin into the ventral tegmental area increased dopamine efflux measured by electrochemical approaches in the prefrontal cortex of anaesthetized rats. In the same conditions, the effects evoked on dopamine efflux by 10(-5)M neurotensin(8-13) and [D-Tyr(11)]neurotensin were different from each other and depended on the explored area: the prefrontal cortex and the caudal and rostral nucleus accumbens. In the prefrontal cortex, neurotensin(8-13) was as potent as neurotensin, whereas [D-Tyr(11)]neurotensin was ineffective. In the caudal nucleus accumbens, when considering the initial intensity of the effect, neurotensin(8-13) and neurotensin appeared more potent than [D-Tyr(11)]neurotensin. In contrast, in the rostral nucleus accumbens, neurotensin(8-13) was less potent than [D-Tyr(11)]neurotensin and neurotensin. These results support the differential involvement of two pharmacologically distinct neurotensin receptor entities on ventral tegmental area neurons in the modulation of mesolimbic and mesocortical dopaminergic activity.
Starting Page	485
Ending Page	492
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/S0306-4522(00)90023-X
PubMed reference number	10869842
Journal	Medline
Volume Number	98
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S030645220090023X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S030645220090023X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0306-4522%2800%2990023-X
Journal	Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article