NDLI: Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.

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Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.

Content Provider	Semantic Scholar
Author	Kurt-Jones, Evelyn A. Dunn, Ian Frederick Ferretti, Massimo Golenbock, Douglas T.
Copyright Year	1998
Abstract	Septic shock induced by lipopolysaccharide (LPS) triggering of cytokine production from monocytes/macrophages is a major cause of morbidity and mortality. The major monocyte/macrophage LPS receptor is the glycosylphosphatidylinositol (GPI)-anchored glycoprotein CD14. Here we demonstrate that CD14 coimmunoprecipitates with Gi/Go heterotrimeric G proteins. Furthermore, we demonstrate that heterotrimeric G proteins specifically regulate CD14-mediated, LPS-induced mitogen-activated protein kinase (MAPK) activation and cytokine production in normal human monocytes and cultured cells. We report here that a G protein binding peptide protects rats from LPS-induced mortality, suggesting a functional linkage between a GPI-anchored receptor and the intracellular signaling molecules with which it is physically associated.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dunnlab.bwh.harvard.edu/wp-content/uploads/2015/04/Solomon-1998-heterotrimeric-G-proteins-physically-associated-w-LPS-receptor-CD14-JCI.pdf
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/4000/4317/JCI9804317.pdf
PubMed reference number	9835628v1
Volume Number	102
Issue Number	11
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	CD14 Antigen CELF Proteins Glycosylphosphatidylinositols Interleukin Receptor Common gamma Subunit Lipopolysaccharides Mitogen-Activated Protein Kinases Mitogens Monocytes Morbidity - disease rate Septic Shock cytokine production genetic linkage
Content Type	Text
Resource Type	Article

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