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Is noncurative gastrectomy always a beneficial strategy for stage IV gastric cancer?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Chang Min Choi, Is. Kim, Jong-Han Park, Da Won Kim, Jun Suk Park, S. |
| Copyright Year | 2017 |
| Abstract | PURPOSE The purpose of this study is to suggest a treatment strategy for stage IV gastric cancer by investigating the behavioral difference between initially and recurrent metastatic disease. METHODS We reviewed the medical records of the patients who underwent chemotherapy alone for metastatic gastric cancer between January 2006 and September 2013. Patients were divided into those who underwent chemotherapy for metastatic disease since initial diagnosis (IM group) and for metastatic recurrence after curative surgery (RM group). Survival and causes of death were compared between the 2 groups, and significant prognostic factors were also investigated. RESULTS A total of 170 patients were enrolled in this study. Of these patients, 104 were included in the IM group and 66 in the RM group. Overall survival of the IM group did not differ from that of RM (P = 0.569). In the comparison of the causes of death, the IM group had a greater tendency to die from bleeding (P = 0.054) and pneumonia (P = 0.055). In multivariate analysis, bone metastasis (P < 0.001; HR = 2.847), carcinoma peritonei (P = 0.047; HR = 1.766), and the frequency of chemotherapy (P < 0.001; HR = 0.777) were significantly associated with overall survival of IM group. CONCLUSION Disease-burden mainly contributes to the prognosis of metastatic gastric cancer, although noncurative gastrectomy may be helpful in reducing the mortality of initially metastatic disease. Therefore, disease-burden should be also prioritized in determining the treatment strategies for stage IV gastric cancer. |
| Starting Page | 23 |
| Ending Page | 27 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 5234432 |
| Alternate Webpage(s) | https://doi.org/10.4174/astr.2017.92.1.23 |
| DOI | 10.4174/astr.2017.92.1.23 |
| Journal | Annals of surgical treatment and research |
| Volume Number | 92 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bronchioloalveolar Adenocarcinoma Cessation of life Forecast of outcome Gastrectomy Hemorrhage Malignant neoplasm of stomach stage IV Metastatic Neoplasm Mohs Surgery Neoplasm Metastasis Overall Survival Patients Pneumonia Postgastrectomy Syndromes Prognostic Factors Stage IV Ovarian Carcinoma Stomach Carcinoma Survival Rate bone metastases stage IV childhood Hodgkin's lymphoma stage IV childhood liver cancer |
| Content Type | Text |
| Resource Type | Article |
