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Alterations in sleep EEG synchrony in combat-exposed veterans with PTSD.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Srinivas Laxminarayan Wang, Chao Sridhar Ramakrishnan Oyama, Tatsuya Cashmere, J. David Germain, Anne Reifman, Jaques |
| Copyright Year | 2020 |
| Abstract | STUDY OBJECTIVES We assessed whether the synchrony between brain regions, analyzed using electroencephalography (EEG) signals recorded during sleep, is altered in subjects with post-traumatic stress disorder (PTSD) and whether the results are reproducible across consecutive nights and subpopulations of the study. METHODS Seventy-eight combat-exposed veteran men with (n = 31) and without (n = 47) PTSD completed two consecutive laboratory nights of high-density EEG recordings. We computed a measure of synchrony for each EEG channel-pair across three sleep stages [rapid eye movement (REM) and non-REM stages 2 and 3] and six frequency bands. We examined the median synchrony in nine region-of-interest (ROI) pairs consisting of six bilateral brain regions (left and right frontal, central, and parietal regions) for ten frequency-band and sleep-stage combinations. To assess reproducibility, we used the first 47 consecutive subjects (18 with PTSD) for initial discovery and the remaining 31 subjects (13 with PTSD) for replication. RESULTS In the discovery analysis, five alpha-band synchrony pairs during non-REM sleep were consistently larger in PTSD subjects compared to controls (effect sizes ranging from 0.52 to 1.44) across consecutive nights: two between the left-frontal and left-parietal ROIs, one between the left-central and left-parietal ROIs, and two across central and parietal bilateral ROIs. These trends were preserved in the replication set. CONCLUSION PTSD subjects showed increased alpha-band synchrony during non-REM sleep in the left fronto-parietal, left centro-parietal, and inter-parietal brain regions. Importantly, these trends were reproducible across consecutive nights and subpopulations. Thus, these alterations in alpha synchrony may be discriminatory of PTSD. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/sleep/zsaa006 |
| PubMed reference number | 31971594 |
| Journal | Medline |
| Alternate Webpage(s) | https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsaa006/31946175/zsaa006.pdf |
| Alternate Webpage(s) | https://doi.org/10.1093/sleep%2Fzsaa006 |
| Journal | Sleep |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
