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Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD
| Content Provider | Scilit |
|---|---|
| Author | Ginsberg, Jay P. Ayers, Edwin Burriss, Louisa Powell, Donald A. |
| Copyright Year | 2008 |
| Description | Disruption of bradycardia associated with discriminative conditioning in combat veterans with PTSD Jay P Ginsberg1,2, Edwin Ayers3, Louisa Burriss1, Donald A Powell1,41Shirley L. Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, SC, USA; 2Department of Pharmacology, Physiology, and Neuroscience, School of Medicine, 4Department of Psychology, University of South Carolina, Columbia, SC, USA; 3Department of Psychology, South Carolina State University, Orangeburg, SC, USA The effects of combat-related posttraumatic stress disorder (PTSD) on heart rate (HR) responding associated with a discriminative delay eyeblink (EB) conditioning paradigm are reported. Combat PTSD+, Combat PTSD−, and Noncombat PTSD− veterans were assessed with psychometric self-report measures, and baseline heart rate variability (HRV) was measured before receiving a 72-trial session of discriminative EB classical conditioning. Two types (red or green light) of conditioned stimuli (CS) were used: one (CS+) predicted a tone, followed immediately by an aversive stimulus (corneal airpuff); the other (CS−) predicted a tone alone, not followed by the airpuff. The light signal was presented for 5 seconds, during which HR was measured. On all psychometric measures, the PTSD+ subgroup was significantly different from the PTSD− subgroups (Combat + Noncombat), and the PTSD− subgroups did not significantly differ from each other. A linear deceleration in HR to CS+ and CS− signals was found in the combined PTSD− subgroup and on CS− trials in the PTSD+ subgroup, but was not present on CS+ trials in the PTSD+ subgroup. Results are interpreted with respect to a behavioral stages model of conditioned bradycardia and in terms of neural substrates which are both critical to HR conditioning and known to be abnormal in PTSD.Keywords: bradycardia, PTSD, combat veterans, classical conditioning |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526370/pdf https://www.dovepress.com/getfile.php?fileID=3012 |
| Ending Page | 646 |
| Page Count | 12 |
| Starting Page | 635 |
| ISSN | 11766328 |
| e-ISSN | 11782021 |
| DOI | 10.2147/ndt.s2808 |
| Journal | Neuropsychiatric disease and treatment |
| Issue Number | 3 |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2008-06-01 |
| Access Restriction | Open |
| Subject Keyword | Biological Psychology Bradycardia Classical Conditioning Combat Veterans |
| Content Type | Text |
| Resource Type | Article |
