NDLI: Local opiate withdrawal in locus coeruleus in vivo

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Local opiate withdrawal in locus coeruleus in vivo

Content Provider	Semantic Scholar
Author	Aston-Jones, Gary S. Hirata, Harumitsu Akaoka, Hideo
Copyright Year	1997
Abstract	Hyperactivity of noradrenergic locus coeruleus (LC) neurons following withdrawal from chronic opiates has been implicated in the opiate withdrawal syndrome. Here, we report that local withdrawal induced in vivo by microinfusion of an opiate antagonist into the LC of morphine-dependent rats marginally, but significantly, activated LC neurons above the level obtained with local naloxone microinfusion in naive rats. This local withdrawal response contributes a significant fraction (approximately 19%) of the total LC hyperactivity induced by systemic naloxone.
Starting Page	331
Ending Page	336
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(97)00682-3
PubMed reference number	9313908
Journal	Medline
Volume Number	765
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899397006823
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899397006823?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	http://academicdepartments.musc.edu/neuromodulation/epapers/akaoka-Aston-JonesBrainRes97.pdf
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2897%2900682-3
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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