NDLI: Lesions to terminals of noradrenergic locus coeruleus neurones do not inhibit opiate withdrawal behaviour in rats

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Lesions to terminals of noradrenergic locus coeruleus neurones do not inhibit opiate withdrawal behaviour in rats

Content Provider	Semantic Scholar
Author	Chieng, Billy Christie, Macdonald J.
Copyright Year	1995
Abstract	The involvement of neurones of the locus coeruleus (LC) in expression of opiate withdrawal behaviour was tested in morphine-dependent rats using N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), a neurotoxin selective for noradrenergic terminals arising from LC. Lesions were validated by determination of cortical noradrenaline concentrations using gas chromatography-mass spectrometry, inhibition of the post-decapitation hindpaw reflex and dopamine-beta-hydroxylase immunohistochemistry. Lesions did not inhibit the expression of any naloxone-precipitated withdrawal signs. These results suggest no involvement of noradrenergic LC neurones in expression of the overt signs of opiate withdrawal, and raise the possibility that previous microinjection and electrolytic lesion studies were confounded by effects on nearby brain regions.
Starting Page	37
Ending Page	40
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(95)11276-3
PubMed reference number	7540267
Journal	Medline
Volume Number	186
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394095112763
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394095112763?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2895%2911276-3
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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