NDLI: Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats

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Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats

Content Provider	Semantic Scholar
Author	Markowska, Anna I. Rebuffat, Piera Rocco, Stefano Gottardo, Giuseppe Mazzocchi, Giuseppina Nussdorfer, Gastone Giovanni
Copyright Year	2004
Abstract	Within two weeks, hypophysectomy induced in rats a striking decrease in the level of circulating ACTH (the concentration of which was at the limit of sensitivity of our assay system), coupled with a net reduction in the plasma corticosterone concentration and an evident adrenal atrophy. Zona fasciculata, the main producer of glucocorticoids, was decreased in volume, due to a lowering in both the number and average volume of its parenchymal cells. Subcutaneous ACTH infusion (0.1 pmol·min-1), administered during the last week following hypophysectomy, restored the normal blood level of ACTH and completely reversed all effects of hypophysectomy on the adrenals. Subcutaneous infusion for one week with α-helical-CRH or corticotropin-inhibiting peptide (1 nmol·min-1), which are competitive inhibitors of CRH and ACTH, evoked a further significant lowering of plasma corticosterone concentration and markedly enhanced adrenal atrophy in hypophysectomized rats. These findings strongly suggest that an extrahypothalamic pituitary CRH/ACTH system may be involved in the maintenance of the growth and steroidogenic secretory activity of the rat adrenal cortex.
Starting Page	439
Ending Page	445
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1007/BF00318550
PubMed reference number	8393384
Journal	Medline
Volume Number	272
Alternate Webpage(s)	https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF00318550
Alternate Webpage(s)	https://doi.org/10.1007/BF00318550
Journal	Cell and Tissue Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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