NDLI: Curcumin Induces Recovery from Indomethacin-Induced Gastric Mucosal Lesions in Rats

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Curcumin Induces Recovery from Indomethacin-Induced Gastric Mucosal Lesions in Rats

Content Provider	Semantic Scholar
Author	Kim, Jisun Kim, Byung-Woo Kwon, Hyun-Ju Kim, Yeon-Hee Nam, Soo-Wan
Copyright Year	2014
Abstract	In the present study, the curative effect of curcumin on indomethacin-induced gastric mucosal lesions in rats was investigated. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID), with serious side effects, including erosion, ulcerative lesions, and petechial bleeding in the mucosa of the stomach. Gastric mucosal lesions were caused by oral administration of 25 ㎎/㎏ of indomethacin. Various doses (10, 50, and 100 ㎎/㎏) of curcumin were treated for 3 days by oral gavage. Indomethacin clearly increased the gastric ulcer area in the stomach, and curcumin significantly decreased the gastric ulcer area in a dose-dependent manner. Curcumin also markedly inhibited lipid peroxidation in the gastric mucosa and activated radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, in a dose-dependent manner. These results suggest that curcumin can induce recovery from indomethacin-induced gastric mucosal lesions through inhibition of lipid peroxidation and activation of radical scavenging enzymes, such as SOD, catalase, and glutathione peroxidase. Curcumin appears to be a powerful free radical quencher, and it may offer an attractive strategy for healing gastric mucosal lesions in humans.
Starting Page	20
Ending Page	25
Page Count	6
File Format	PDF HTM / HTML
DOI	10.5352/JLS.2014.24.1.20
Volume Number	24
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/ksls/SMGHBM/2014/v24n1/SMGHBM_2014_v24n1_20.pdf
Alternate Webpage(s)	https://doi.org/10.5352/JLS.2014.24.1.20
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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