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Nonlethal, attenuated, transfusion-associated graft-versus-host disease in an immunocompromised child: case report and review of the literature.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Neves, João Farela Marques, Antonio Jose Gameiro. Valente, Rosalina Barata, Deolinda Maria Adonis |
| Copyright Year | 2010 |
| Abstract | BACKGROUND Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of transfusion of nonirradiated blood components. It usually affects children in high-risk groups, including those who have primary immunodeficiencies (PIDs). It usually presents with skin, hepatic, digestive, and hematologic involvement and is normally fatal. CASE REPORT We report the case of a nonlethal, attenuated, TA-GVHD in a 7-month-old boy. The disease was marked by the presence of a severe rash but lacked all the other usual manifestations. We speculate that the unusually benign course of this disease, which has normally a fulminant course, was due to the fact that this child was under high-dose corticotherapy at the time of the engraftment. This fortunate coincidence led to the survival of this child and allowed the diagnosis of a combined immunodeficiency. CONCLUSION A high index of suspicion is required for the diagnosis and proper management of PID. The administration of nonirradiated blood components in the first year of life, sometimes before the clinical suspicion of a PID, is of great concern. TA-GVHD may be more prevalent than reported in the literature and it is possibly a nonidentified cause of death in recipients with unexplained death and nondiagnosed PID. |
| Starting Page | 31 |
| Ending Page | 35 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ammtac.org/data/images/fckeditor/file/Nonlethal,%20attenuated,%20transfusion-associated%20graft-versus-host.pdf |
| Alternate Webpage(s) | http://repositorio.chlc.min-saude.pt/bitstream/10400.17/2525/1/Transfusion%202010_50_2484.pdf |
| PubMed reference number | 20497511v1 |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1537-2995.2010.02705.x |
| DOI | 10.1111/j.1537-2995.2010.02705.x |
| Journal | Transfusion |
| Volume Number | 50 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Addison Disease Blood Component Transfusion Cessation of life Combined immunodeficiency Digestive System Disorders Exanthema Gastrointestinal system Graft versus host disease prophylaxis/therapy Hematology (discipline) Immunologic Deficiency Syndromes NRAS NM_002524.4:c.180_181delACinsTA Pelvic Inflammatory Disease Sudden infant death syndrome Transplanted tissue Triamcinolone Acetonide 1 MG/ML Topical Cream [Pediaderm TA] cytarabine/thioguanine engraftment human papillomavirus vaccine, TA |
| Content Type | Text |
| Resource Type | Article |
